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Conceptual Origin: From Empirical Observation to Theoretical Framework In the 16th century, the Swiss physician Paracelsus established the philosophical foundation for dose-response relationships with his statement, The dose makes the poison ( Sola dosis facit venenum )

By directly introducing B12 into the body through injections, these processes are supported more efficiently, making B12 injections an effective method for addressing deficiencies and promoting overall health

Cell Tissue Res 1996

I wondered if I could find some drugs